"

M6.COM官网

"
科学研究
20220913 CDK14 inhibition reduces mammary stem cell activity and suppresses triple negative breast cancer progression

Zhang, M., Zhang, L., Geng, A., …, Zeng, Y.A.*, Li, J.*, Cai, C.* (2022). CDK14 inhibition reduces mammary stem cell activity and suppresses triple negative breast cancer progression. Cell Rep. (蔡车国)

 

Abstract

The Wnt/β-catenin signaling pathway plays an important role in regulating mammary organogenesis and oncogenesis. However, therapeutic methods targeting the Wnt pathway against breast cancer have been limited. To address this challenge, we investigate the function of cyclin-dependent kinase 14 (CDK14), a member of the Wnt signaling pathway, in mammary development and breast cancer progression. We show that CDK14 is expressed in the mammary basal layer and elevated in triple negative breast cancer (TNBC). CDK14 knockdown reduces the colony-formation ability and regeneration capacity of mammary basal cells and inhibits the progression of murine MMTV-Wnt-1 basal-like mammary tumor. CDK14 knockdown or pharmacological inhibition by FMF-04-159-2 suppresses the progression and metastasis of TNBC. Mechanistically, CDK14 inhibition inhibits mammary regeneration and TNBC progression by attenuating Wnt/β-catenin signaling. These findings highlight the significance of CDK14 in mammary development and TNBC progression, shedding light on CDK14 as a promising therapeutic target for TNBC.

 

全文链接请见:

https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01159-7

 

地 址:湖北省武汉市武昌区东湖路115号 邮政编码:430071 电 话:027-68750205  邮 箱:mri@whu.edu.cn

CopyRight ? 2016  版权所有:武汉大学医学研究院

M6.COM官网
<var id="rv3ff"></var>
<cite id="rv3ff"><video id="rv3ff"></video></cite>
<var id="rv3ff"></var>
<cite id="rv3ff"><span id="rv3ff"><menuitem id="rv3ff"></menuitem></span></cite><var id="rv3ff"><strike id="rv3ff"></strike></var><menuitem id="rv3ff"></menuitem>
<cite id="rv3ff"><span id="rv3ff"><menuitem id="rv3ff"></menuitem></span></cite>
<ins id="rv3ff"></ins>
<cite id="rv3ff"></cite>
<menuitem id="rv3ff"><strike id="rv3ff"></strike></menuitem>
<cite id="rv3ff"><span id="rv3ff"></span></cite><cite id="rv3ff"><video id="rv3ff"><menuitem id="rv3ff"></menuitem></video></cite>"